Proteomic signatures detectable in children may predict an increased risk for cardiovascular-kidney-metabolic disease (CKMD) in later life, offering a potential precision prevention approach to address cardiometabolic diseases at the earliest opportunity.
About Proteome:
A proteome is a set of proteins produced in an organism, system, or biological context.
The proteome is not constant; it differs from cell to cell and changes over time.
The proteome of any given individual will be unique, as protein expression patterns are determined by an individual’s genes.
The proteome is always significantly larger than the number of genes in an individual due to a number of factors:
Gene sequences may be alternatively spliced following transcription to generate multiple protein variants from a single gene.
Proteins may be modified (e.g. glycosylated, phosphorylated, etc.) following translation to promote further variations.
Proteomics is the large-scale study of proteomes.
With each protein playing distinct roles and functions, proteomics provides valuable insights into cellular processes, signaling pathways, and disease mechanisms.
Scientists typically study the proteome using techniques like mass spectrometry or traditional protein sequencing.
Proteomics is used to investigate:
when and where proteins are expressed
rates of protein production, degradation, and steady-state abundance
how proteins are modified (for example, post-translational modifications (PTMs) such as phosphorylation)
the movement of proteins between subcellular compartments
the involvement of proteins in metabolic pathways
how proteins interact with one another
Understanding the proteome can shed light on disease mechanisms, help identify potential drug targets, and develop novel therapeutic interventions.
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