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What is Kikuchi-Fujimoto Disease?

Aug. 19, 2026

A 32-year-old man from Visakhapatnam, who had recurrent lymph node swelling for nearly six years and was repeatedly treated for suspected tuberculosis, has finally been diagnosed with rare Kikuchi–Fujimoto disease recently.

About Kikuchi-Fujimoto Disease:

  • Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenopathy, is a rare inflammatory disorder of the lymph nodes.
  • It causes swollen, painful lymph nodes that most often develop in neck (cervical lymphadenopathy), along with fever and fatigue.
  • It most often affects people aged 30 and under.
  • It can closely mimic tuberculosis and lymphoma.
  • Causes: The cause of KFD remains unclear, but both viral infections and autoimmune mechanisms have been suggested as potential triggers.
  • Usually, this disease does not cause severe problems and gets better on its own.
  • However, in some people, it can be associated with autoimmune disorders, conditions where the immune system mistakenly attacks the body’s cells and tissues.
  • Treatment:
    • There isn’t a specific cure, but certain medication can help to relieve symptoms, including:
      • NSAIDs (nonsteroidal anti-inflammatory drugs), for fever, pain, and headache.
      • Corticosteroids may be used in severe cases to reduce swelling in lymph nodes.

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