Recently, the Ministry of Science and Technology informed about a new smart drug named RK-251 that can replace traditional chemotherapy.
About RK-251 Drug:
It is a smart cancer drug designed to activate primarily in cancer cells and does not harm healthy cells.
Working Mechanism:
When RK-251 enters a cancer cell with high reactive oxygen species (ROS) levels, these molecules trigger the drug’s activation, releasing an anticancer compound called NBDHEX.
NBDHEX blocks target proteins that many cancer cells use to survive and resist treatment.
The idea is to keep RK-251 relatively inactive in normal tissues and activate its anticancer action inside cancer cells.
It exhibited strong activity against aggressive triple-negative breast cancer cells, with much less effect on healthy cells.
It displayed the desired fluorescence in the presence of reactive oxygen species.
The fluorescence response also provides an indication that the drug is being activated in an ROS-rich environment, supporting the underlying mechanism of the targeted approach.
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