Pioxaniliprole
Recently, PI Industries Ltd’s Pioxaniliprole has received approval from the Central Insecticides Board and Registration Committee (CIBRC).
About Pioxaniliprole:
- It is India’s first indigenously discovered insecticide molecule.
- It has been developed by PI Industries Ltd.
- It is an insecticidal active ingredient belonging to the anthranilic diamide class of insecticides.
- Pioxaniliprole’s Chemical Composition: It is a carboxamide compound containing chlorine, nitrogen, oxygen and sulphur atoms.
- Mechanism of action:
- Target insect pests: The insecticide is effective against yellow stem borer, leaf folder, fall armyworm, tobacco cutworm, fruit borer and pod borer.
- It targets ryanodine receptors in insects, causing feeding cessation, muscle paralysis and eventually death.
- Pioxaniliprole acts by targeting ryanodine receptors (RyRs), specialised protein channels present in insect muscle cells that regulate the release of calcium ions from intracellular storage compartments into the cell cytoplasm.
- Calcium ions play a crucial role in normal muscle contraction and relaxation. Pioxaniliprole binds to and activates these receptors, triggering an uncontrolled release of calcium ions.
- This disrupts normal muscle functioning in insects, leading to feeding cessation, lethargy, muscle paralysis and eventually death.
Source: Pioxaniliprole: What makes India’s first indigenously developed insecticide significant?