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Leucine

July 8, 2026

Researchers said that branched chain amino acids leucine acts like a protective shield and inhibits the premature degradation of outer mitochondrial membrane proteins.

About Leucine:

  • Leucine is an essential amino acid.
  • It belongs to the family of branched chain amino acids (BCAA) such as isoleucine and valine.
  • These are needed for the growth and functioning of organs such as muscles, nervous system, the heart, and the brain.
  • BCAAs are not made in the body and need to be supplied from our diet. Without them, the outer membrane of the mitochondrion cannot be properly constructed or maintained. 
  • Functions:
    • It is involved in muscle growth, tissue repair, and energy production
    • It acts like a protective shield and inhibits the premature degradation of outer mitochondrial membrane proteins.
    • This is done by leucine interacting with a protein called SEL1L, which has a role in recognising and pulling out damaged or misfolded proteins.

What are Amino Acids?

  • Amino acids are molecules that combine to form proteins.
  • Amino acids and proteins are the building blocks of life.
  • There are 20 different amino acids.
  • A protein consists of one or more chains of amino acids (called polypeptides) whose sequence is encoded in a gene.
  • Some amino acids can be synthesized in the body, but others (essential amino acids) cannot and must be obtained from a person’s diet.
  • The nine essential amino acids are: histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine.

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