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Lenacapavir

Feb. 24, 2026

Recently, Zimbabwe has begun rolling out lenacapavir, a long-acting injectable HIV prevention medicine.

About Lenacapavir:

  • It is the new long-acting injectable HIV-prevention drug.
  • It is the first twice-yearly injectable pre-exposure prophylaxis (PrEP) for HIV, offering a highly effective, long-acting alternative to daily oral pills.
    • PrEP is a medication that can reduce the risk of HIV infection for individuals who are HIV-negative but are at risk of contracting the virus.
  • The results of two key studies have shown that it helps prevent 99.9 per cent of all HIV transmission.
  • It is developed by Gilead Sciences and marketed under the brand name Yeztugo.
  • How does lenacapavir work?
    • Lenacapavir is a capsid inhibitor, a class of drugs that blocks the protein shell (capsid) the HIV virus needs to replicate.
    • Unlike oral PrEP pills that must be taken daily, lenacapavir is administered as an injection once every six months, providing a discreet and highly effective method of prevention.

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