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Key Facts about Vitamin B3

June 24, 2026

A clinical trial is exploring whether high doses of vitamin B3 could give patients with glioblastoma a better chance against aggressive brain cancer.

About Vitamin B3:

  • Vitamin B3, or Niacin, is a water-soluble vitamin.
    • Water-soluble vitamins dissolve in water. Leftover amounts of the vitamin leave the body through the urine.
    • The body keeps a small reserve of these vitamins, but they have to be taken on a regular basis to maintain the reserve.
  • It is naturally present in many foods, added to some food products, and available as a dietary supplement.
  • The body gets niacin through food, but it also makes small amounts from the amino acid tryptophan, which can be found in protein sources like turkey and other animal foods.
  • The two most common forms of niacin in food and supplements are nicotinic acid and nicotinamide.
  • Functions:
    • Niacin works in the body as a coenzyme, with other enzymes dependent on it for various reactions.
    • Niacin helps to convert nutrients into energy, create cholesterol and fats, create and repair DNA, and exert antioxidant effects.
    • Due to Niacin's positive effects on cholesterol levels, it may help prevent heart disease.
    • Additionally, it may reduce oxidative stress and inflammation, which are associated with atherosclerosis, or the hardening of the arteries.
  • Food Sources: It is found in many foods, both from animals and plants.
    • Red meat: beef, beef liver, pork
    • Poultry
    • Fish
    • Brown rice
    • Fortified cereals and breads
    • Nuts, seeds
    • Legumes
    • Bananas
  • Deficiency:
    • A severe niacin deficiency leads to pellagra, a condition that causes a dark, sometimes scaly rash to develop on skin areas exposed to sunlight; bright redness of the tongue; and constipation/diarrhea.
    • Other signs of severe niacin deficiency include:
      • Depression
      • Headache
      • Fatigue
      • Memory loss

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