About Intrinsically Disordered Proteins:
- Intrinsically disordered proteins are defined as proteins or regions of proteins that lack a fixed or ordered three-dimensional structure under biological conditions.
- Other Names: Also called natively unfolded or intrinsically unstructured proteins.
- These are important for cellular signaling and regulation.
- Functions of Intrinsically Disordered Proteins:
- They are shape shifting molecules vital to cellular communication.
- They don’t form a fixed structure.
- They guide signalling networks.
- They help proteins move and find partners within the cell, regulate which genes are switched on or off,
- IDP support protein folding and quality control, and assemble flexible cellular hubs called condensates.
Key Facts about Disobind Tool
- It is developed by the researchers of National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research, Bengaluru.
- Features of Disobind Tool
- It is open-source and freely available for researchers worldwide.
- It analyses the protein sequences and uses protein language models (a form of AI trained on millions of known protein sequences).
- No structural info needed: It does not require any structural information or sequence alignments, making it super convenient.
- High accuracy: Disobind outperformed popular tools like AlphaFold-multimer and AlphaFold3 in tests on new protein pairs.
- Disobind delivered consistently higher accuracy when tested on new protein pairs it had not seen before.
- Applications of the tool could span from disease biology to drug design.
