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Autophagy

Dec. 21, 2025

Researchers have uncovered a surprising player in autophagy process that can pave the way for developing therapies for diseases such as Alzheimer’s, Parkinson’s, and cancer.

About Autophagy:

  • It is a key biological process where cells clear out damaged and unwanted materials.
  • The autophagy pathway, which removes damaged material and defends against infections, is disrupted in diseases like Alzheimer’s and Huntington’s.
  • When a cell fails to clear waste, its health suffers, especially in long-lived neurons.
  • Autophagy is body’s cellular recycling system.
  • It allows a cell to disassemble its junk parts and repurpose the salvageable bits and pieces into new, usable cell parts.
  • Importance of autophagy:
    • It recycles damaged cell parts into fully functioning cell parts.
    • It gets rid of nonfunctional cell parts that take up space and slow performance.
    • It destroys pathogens in a cell that can damage it, like viruses and bacteria.
    • Autophagy plays an important role when it comes to aging and longevity, too. 
  • Autophagy and Disease Linkages
    • Autophagy initially prevents cancer but later supports tumour growth and acts as a tumour suppressor by maintaining genome integrity and cellular homeostasis.
    • In certain types of cancer, cells hijack autophagy for their own survival and propagation.

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